![]() ![]() 25 mg once weekly gives a slower response and may be less effective. Methotrexate, glucocorticoids, salicylates, nonsteroidal anti- inflammatory drugs (NSAIDs), or analgesics may be continued during treatment with Etanercept in adults. Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: Patients aged 18 years or older- 50 mg Etanercept per week administered either once weekly (as one subcutaneous injection using a 50 mg syringe or as two 25 mg injections given at the same time) or 25 mg Etanercept twice weekly (72 to 96 hours apart) as a subcutaneous injection. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA) and the resulting joint pathology. Elevated levels of TNF are found in the synovial fluid of RA patients. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. ![]() Etanercept is a TNF alpha inhibitor that binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. It consists of 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. This is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. Pediatric patients with Plaque Psoriasis (PsO): Etanercept is indicated for the treatment of chronic severe plaque psoriasis in children and adolescents from the age of 6 years, who are inadequately controlled by or are intolerant to systemic therapies or phototherapies.Įtanercept is a tumor necrosis factor (TNF) blocker. Etanercept can be used in combination with methotrexate (MTX) in patients who do not respond adequately to MTX alone.Īdults with Ankylosing Spondylitis (AS): Etanerceptis indicated for reducing signs and symptoms in patients with active ankylosing spondylitis (AS).Īdults with Plaque Psoriasis (PsO): Etanercept is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis (PsO) who are candidates for systemic therapy or phototherapy. Pediatric patients with Juvenile Idiopathic Arthritis(JIA): Etanercept indicated for the treatment of polyarticular-course juvenile idiopathic arthritis (JIA) in children and adolescents from the age of 2 years when the response to one or more DMARDs has proven inadequate.Īdults with Psoriatic Arthritis (PsA): Etanercept is indicated for reducing signs and symptoms, inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis (PsA). ![]() Etanercept can be initiated in combination with methotrexate (MTX) or used alone for the treatment of active rheumatoid arthritis (RA) in adults when one or more disease modifying antirheumatic drugs (DMARDs), including methotrexate (unless contraindicated), has proved inadequate. It should be avoided by people who are allergic to latex, are pregnant or are planning to do so, have been in close proximity to a person with chicken pox.Adults with Rheumatoid Arthritis (RA): Etanercept indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis (RA). It can also weaken the heart and lead to heart problems. It can also lead to nervous system problems such as sclerosis and seizures. The drug is especially dangerous for people with chickenpox. Patents with serious infections are advised to use it with caution and doctor's prescription. ![]() Some cases of cancers have also been reported in children. It can also aggravate or lead to serious conditions like fungal infections, sepsis, or tuberculosis. Some common side effects include pain, headache, itching, bruising, sore throat, redness, swelling and dizziness. Intacept 50mg Injection is US FDA approved, but has some side effects as well. It is usually injected in the body and shows results in 2-10 weeks. Intacept 50mg Injection blocks the TNF (tumor necrosis factor alpha) that causes inflammation. Intacept 50mg Injection is a biological medicine which is used for treating inflammatory conditions such as rheumatoid arthritis, plaque psoriasis, ankylosing spondylitis, psoriatic arthritis, polyarticular juvenile idiopathic arthritis. ![]()
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